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The first ever isothermal envelope: invented by a medium-sized business !

Two small businesses have combined their expertise to bring you the first ever isothermal mailing envelope. A winning strategy !

Having an easy means to ship heat-sensitive products in small quantities, such as vaccines, insulin or hormones, while keeping them at their ideal temperature, is a key issue for pharmaceutical laboratories. Hence the bold idea of Lisotherme, a company based near Paris that has recently joined forces with Harryplast, a small business in the north of France specialising in the manufacture of plastic pouches and packaging materials, to launch the first ever isothermal mailing envelope. In the words of François Ducrocq, president of Lisotherme: "This is an excellent industrial partnership agreement that will allow both parties to accelerate the process to market, while minimising prices and opening up new opportunities".

enveloppe postale isotherme Lisotherme 
Photo credits : Lisotherme 
isothermal mailing envelope

 

This technological innovation is offers a significant benefit over bulkier solutions such as polystyrene containers, which require the carrier's intervention and are problematic when it comes to recycling. Up to five times less bulky and as easy to use as an ordinary envelope, it comprises two 40mm shockproof insulating layers manufactured from natural cotton fibre (i.e. 80mm total thickness). Two sealable protective polyethylene bags, one on the inside and one on the outside, mean that the resulting isothermal envelope is both waterproof and tear-proof. One of the key innovations lies in the wide seals inside, which prevent the heat-sensitive product from hitting the sides and getting close to the ends.

"This envelope is able to keep the product at between 2 and 8°C for more than 48 hours mid-season," confirms the CEO of Lisotherme, which manufactures the condensation-absorbing refrigerant gel that maintains the ideal temperature and keeps the weight of the envelope down to 1.5kg.

Chantal Houzelle

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Date: 07/02/13

JLA Logistique: an isothermal envelope for shipping vaccines through the post

"made up of several layers of polyethylene film covered with two 40mm insulating layers, embedded in a metallised plastic film, this new envelope is tear-proof, waterproof, opaque and secure thanks to its tamper-proof seal". © HarryPlast

Geneviève Hermann, Lille  The companies HarryPlast and Lisotherm have worked together to come up with an mailing envelope that keeps the products transported at between 2 and 5 °C for 48 hours. This patented innovation could transform the methods used to transport temperature-sensitive health products such as vaccines, hormones and antiallergens.

Harry Plast, specialists in the design and manufacture of plastic envelopes and pouches, have chosen to tackle another extremely promising market: that of postal delivery of temperature-sensitive health products such as vaccines, antiallergens, insulin and hormones. Together with Lisotherme, a young Yvelines-based company that has granted a licence to use its refrigerant gel, the medium-sized business from Saint Amand Les Eaux (turnover of 4.75 million euros) has come up with an isothermal envelope that can keep contents at between + 2 and + 5°C for at least 48 hours, the time needed to deliver it to its destination. This maintains the cold chain required for healthcare applications.

According to Guillaume Petit, sales and marketing director for Harry Plast, there is no comparable product available on the market. "While conventional refrigerant-based solutions cause the products to degrade by exposing them to sub-zero temperatures, leading to a freeze-thaw effect, our refrigerant gel eliminates this risk, creating a zero degree surface temperature," explains François Ducrocq, present of Lisotherme. Unlike the insulated containers traditionally used, Harry Plast envelopes do not require carrier intervention. A simple stamp or franking is all that is required.

tamper-proof closure

Made up of several layers of polyethylene film covered with two 40mm insulating layers, embedded in a metallised plastic film, this new envelope is tear-proof, waterproof, opaque and secure thanks to its tamper-proof seal. Wide inner seals prevent the transported product from getting close to the edges of the envelope where thermal bridges may reduce the performance of the gel.

The two companies have worked together for a year and a half on this new packing solution. The National Laboratory for Metrology and Testing (LNME) has validated its performance in accordance with standard NF S99-700 ST48 governing the transportation of temperature-sensitive products. With each company bringing its expertise to the table, Lisotherme and HarryPlast have together succeeded in optimising the technical characteristics of this isothermal plastic packaging solution while reducing design costs. The new packaging has just gone on sale. The company is already considering the international market.

 

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Lisotherme: Cooling specialists

07/02/2013, 16:35

(Boursier.com) -- Shares in the company Lisotherme are listed on Alternativa or Alternativa/Lisotherme as ISIN FR0011047141 and stock symbol AALIS.

Cooling is Lisotherme's best friend. Or rather, it is the company's speciality, as the core business of the company, founded in September 2007, was originally refrigerants. Following an initial patent for a condensation-absorbing refrigerant gel, the company founded by François Ducroq and Kim Huynh diversified into cardboard-based isothermal packaging and exclusively natural products as a replacement to polystyrene. These ground breaking solutions, which have surpassed the competition on several occasions, have enabled this small company to grow quickly and above all to acquire an industry client base of more than 500 companies.

On the basis of this success, in 2011, the company saw turnover of 573,774 euros compared to 561,310 one year previously.

Nonetheless, the company's operating results remained in the red, registering losses of 131,299 euros compared to 39,044 euros in 2010 due to steep rises in operating costs. These rose by 17.44% to 705,073 euros compared to 600,354 euros in 2010. Finally, financial year 2011 closed with losses of 106,946 euros compared to a 5,515 euro profit the year befores.

Despite this drop in net profitability, the company's financial position remains healthy. As of 31 December 2011, the company's equity stood at 251,576 euros against liabilities of 19,976 euros.

Based on a market capitalisation of 1.53 million euros on 21 December 2012, we feel the company is correctly valued on the Alternativa stock market. We await a return to profit in order to recommend investment.

 

Shares in Lisotherme are listed on the Alternativa market under ISIN FR0011047141 and stock code AALIS.

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Isothermal mailing envelope

13 February 2013, by Gilles Solard

Harryplast and Lisotherme, two French companies, have developed the first ever isothermal mailing envelope with a refrigeration period of more than 48 hours.

A patented innovation enabling health products to be transported at between +2°C and +8°C, such as vaccines, antiallergens, insulin or hormones. The guaranteed temperature preservation has been validated by the National Laboratory for Metrology and Testing in accordance with the NF S99-700 ST48 standard. 
According to the companies, eutectic salts cause degradation to the products, exposing them to sub-zero temperatures. Lisotherme believe that they eliminate this risk by instead creating a zero surface temperature, which is suitable for biological drugs or those sensitive to temperature fluctuations. Isothermal containers and coolers, on the other hand, are bulky and incur additional cost. 
Technically, the envelope is made up of two 40mm shockproof insulators. It is tear-proof and waterproof. With a thickness of 80mm and a weight of 1.5kg (including the refrigerant gels), it meets requirements of standard NF S99 700 for the transportation of temperature-sensitive products, providing 48 hours ST c and d Located in Saint Amand les Eaux, Harryplast manufactures envelopes, pouches and packaging solutions, while Lisotherme produces refrigerant gels and isothermal packaging at its Coignières site. It won the INPI Paris region Trophy for Innovation in 2010.

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Harry Plast and Lisotherme invent the 48 hour isothermal mailing envelope

harryplastFor the shipment of temperature-sensitive pharmaceutical products, French companies Harry Plast (based in Saint-Amand, Nord region) and Lisotherme (Coignières, Yvelines) have developed the first ever isothermal mailing envelope with a refrigeration period greater than 48 hours. Marketed by the two companies together, this patented technology conserves the cold chain and provides an alternative to existing distribution channels.
   
 
HARRYPLAST breaks new ground: the first ever 48 hour isothermal mailing envelope
 
 
HARRYPLAST
Increasing need for isothermal packaging in the pharmaceutical sector
A growing number of health products need to be kept at between +2°C and +8°C: vaccines, antiallergens, insulin, hormones, etc. Preserving the cold chain which ensures the efficacity of these temperature-sensitive health products and the safety of the patient represents a considerable issue when it comes to their transportation. While no accurate figures are available, the risk of temperature-sensitive medicines being affected when the cold chain is broken are well-established. Keeping products cool is a key issue for laboratories, distributors and logistics service providers.  
Proven preservation of cold temperatures above zero for 48 hours
The 48 hour isothermal mailing envelope guarantees a constant temperature of around 2-5° for more than 48 hours, unrivalled performance which has been validated by the National Laboratory for Metrology and Testing in accordance with the NF S99-700 ST48 standard.  While conventional eutectic salts cause degradation to the products, exposing them to sub-zero temperatures, creating a freeze-thaw effect, Lisotherme's refrigerant gel eliminates this risk, creating a 0° surface temperature. A technological advance that is particularly suited to biological drugs or those produced through bio-medical engineering, which are even more sensitive to fluctuations in temperature. 
A new method of shipment
When it comes to the transportation of temperature-sensitive products, existing solutions (isothermal containers or cool boxes and cool bags) are heavy and bulky, and handling them requires making prior arrangements with the carrier and incurs additional transportation costs. Up to five times less bulky, the envelope format developed by HarryPlast is light and easy to handle. With its writable surface, which is also suitable for affixing adhesive media, the product is ready top ship by post in a matter of minutes.  
Technical information
The envelope comprises two 40mm shock-resistant isothermal insulating layers. It is tamper-proof, tear-proof and leak-proof. With a thickness of 80[mm] and weighing 1.5kg, the external dimensions are 310x420mm. The envelope meets the 48 hours requirement set out in the NF S99 700 standard for the shipment of temperature-sensitive products press release.
 
About HarryPlast :
A medium-sized business located in St Amand les Eaux (Nord region), Harry Plast has been manufacturing and distributing mailing envelopes, secure pouches and plastic packaging solutions since 1979. Awarded the INPI Trophy for Innovation in Nord-Pas-de-Calais in 2002 and the Euro-Region Trophy in 2003, HarryPlast has a current turnover of 4.8 million euros and allocates 2-3% of its turnover to R&D. The company ISO 14001 certified. 
About Lisotherme :
Lisotherme is a young company with 9 employees that produces refrigerant gels and isothermal packaging at its production unit in Coignières (Yvelines). The company, founded in 2007, has gained the trust of both major manufacturing and pharmaceutical groups and small-scale companies. The company was awarded the 2010 Innovation Trophy by the Paris branch of the INPI

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> Health Strategy Article

A French innovation: the first ever isothermal mailing envelope

Publication date: 20 February 2013

 

HarryPlast and Lisotherme* have developed the first ever isothermal mailing envelope with a refrigeration time of more than 48 hours, assisting in the shipment of temperature-sensitive pharmaceutical products .

Marketed by the two companies in collaboration, this patented technology preserves the cold chain and provides an alternative to existing distribution channels.

A growing number of health products need to be kept at between +2°C and +8°C: vaccines, antiallergens, insulin, hormones, etc. Preserving the cold chain which ensures the efficacity of these temperature-sensitive health products and the safety of the patient represents a considerable issue when it comes to their transportation. While no accurate figures are available, the risk of temperature-sensitive medicines being affected when the cold chain is broken are well-established. Preservation of cold temperatures is a key issue for laboratories, distributors and logistics companies.

The 48 hour isothermal mailing envelope guarantees a constant temperature of around 2-5° for more than 48 hours, unrivalled performance which has been validated by the National Laboratory for Metrology and Testing in accordance with the NF S99-700 ST48 standard. While conventional eutectic salts cause degradation to the products, exposing them to sub-zero temperatures, creating a freeze-thaw effect, Lisotherme's refrigerant gel eliminates this risk, creating a 0° surface temperature. An advanced technology particularly suited to biological or bio-engineered drugs, which are even more sensitive to fluctuations in temperature.

For the transportation of temperature-sensitive products, existing solutions (isothermal containers or cool boxes and cool bags) are heavy and bulky, and handling them requires making prior arrangements with the carrier and incurs additional storage and transportation costs. Up to five times less bulky, the envelope format developed by HarryPlast is light and easy to handle. With its writable surface, which also allows adhesive media to be affixed, the product is ready to ship by post in a matter of minutes.

The envelope is made up of two 40mm shockproof isothermal layers.  It is tamper-proof, tear-proof and leak-proof. With a thickness of 80[mm] and weighing 1.5kg, the external dimensions are 310x420mm. The envelope meets the 48 hours requirement set out in the NF S99 700 standard for the shipment of temperature-sensitive products.

* HarryPlast is a medium-sized business located in St Amand les Eaux (Nord region). Harry Plast has been manufacturing and distributing plastic packaging solutions since 1979. Awarded the INPI Trophy for Innovation in Nord-Pas-de-Calais in 2002 and the Euro-Region Trophy in 2003, HarryPlast has a current turnover of 4.8 million euros and allocates 2-3% of its turnover to R&D. The company ISO 14001 certified.

* Lisotherme is a young company with 9 employees that produces refrigerant gels and isothermal packaging at its production unit in Coignières (Yvelines). The company, founded in 2007, has gained the trust of both major manufacturing and pharmaceutical groups and small-scale businesses. It won the INPI Paris region Trophy for Innovation in 2010.


Press contact: Laurence ZEERARD

06.15.90.86.22 rpharryplast@gmail.com

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